Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment.[11] These diseases include hay fever, food allergies, atopic dermatitis, allergic asthma, and anaphylaxis.[1] Symptoms may include red eyes, an itchy rash, sneezing, coughing, a runny nose, shortness of breath, or swelling.[12] Note that food intolerances and food poisoning are separate conditions.[3][4]
Common allergens include pollen and certain foods.[11] Metals and other substances may also cause such problems.[11] Food, insect stings, and medications are common causes of severe reactions.[2] Their development is due to both genetic and environmental factors.[2] The underlying mechanism involves immunoglobulin E antibodies (IgE), part of the body's immune system, binding to an allergen and then to a receptor on mast cells or basophils where it triggers the release of inflammatory chemicals such as histamine.[13] Diagnosis is typically based on a person's medical history.[3] Further testing of the skin or blood may be useful in certain cases.[3] Positive tests, however, may not necessarily mean there is a significant allergy to the substance in question.[14]